Article

CDK8 is a critical effector of cell fate dysregulation in <i>SF3B1</i> -mutant MDS

2025-08-19

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in RNA splicing factor SF3B1 are among the most common in MDS and are strongly associated with MDS with ring sideroblasts (MDS-RS). While aberrant splicing of terminal erythroid regulators has been implicated in MDS pathogenesis, the impact of SF3B1 mutations on early hematopoietic progenitor function remains unclear. Here, we identify CDK8, a key kinase of the mediator complex invol...

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Literature Corpus work: 477768ec-c9a9-5c49-8eaf-3d834525d7c9
DOI: 10.1101/2025.08.14.670174

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