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Article

Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci.

American journal of human genetics - 2 Jul 2015

Trynka Gosia, Westra Harm-Jan, Slowikowski Kamil, Hu Xinli, Xu Han, Stranger Barbara E, Klein Robert J, Han Buhm, Raychaudhuri Soumya

Abstract excerpt

Identifying genomic annotations that differentiate causal from trait-associated variants is essential to fine mapping disease loci. Although many studies have identified non-coding functional annotations that overlap disease-associated variants, these annotations often colocalize, complicating the ability to use these annotations for fine mapping causal variation. We developed a statistical approach (Genomic...

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Identifiers

PMID: 26140449
DOI: 10.1016/j.ajhg.2015.05.016
PMCID: PMC4572568

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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