Article

Arid5a mediates an IL-17-dependent pathway that drives autoimmunity but not antifungal host defense

2022-02-14

Abstract excerpt

IL-17 contributes to the pathogenesis of certain autoimmune diseases, but conversely is essential for host defense against fungi. Antibody-based biologic drugs that neutralize IL-17 are effective in autoimmunity but can be accompanied by adverse side effects. Candida albicans is a commensal fungus that is the primary causative agent of oropharyngeal and disseminated candidiasis. Defects in IL-17 signaling cause s...

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Literature Corpus work: 8f183bf0-2f2f-5615-a7a3-1f5fbd441d8e
DOI: 10.1101/2022.02.14.480386

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