Arid5a stabilizes OX40 mRNA in murine CD4 + T cells by recognizing a stem‐loop structure in its 3′UTR

Abstract excerpt

Abstract AT‐rich interactive domain‐containing protein 5a (Arid5a) is an RNA‐binding protein (RBP) required for autoimmunity via stabilization of interleukin‐6 ( Il6 ) and signal transducer and activator of transcription 3 ( STAT3 ) mRNAs. However, the roles of Arid5a in Th17 cells and its association with autoimmunity remain unknown. Here, we show that the levels of Arid5a and OX40 are correlated in CD4 + T...

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