Article

A loss-of-function mutation in IL-17F enhances susceptibility of mice to oropharyngeal candidiasis

2020-04-11

Abstract excerpt

Oropharyngeal candidiasis (OPC) is an opportunistic infection of the oral mucosa caused by the commensal fungus C. albicans . IL-17 receptor signaling is essential to prevent OPC in mice and humans, but the individual roles of its ligands, IL-17A, IL-17F and IL-17AF, are less clear. A homozygous IL-17F deficiency in mice does not cause OPC susceptibility, whereas mice lacking IL-17A are moderately susceptible. In...

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Literature Corpus work: b909e5f5-35c9-5701-b045-c38f11f89a1e
DOI: 10.1101/2020.04.09.028027

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