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Alterations in Blood Methylome as Potential Epigenetic Biomarker in Sporadic Parkinson's Disease

2 Apr 2024

Abstract excerpt

OBJECTIVE: To characterize DNA methylation (DNAm) differences between sporadic Parkinson's disease (PD) and healthy control (HC) individuals enrolled in the Parkinson's Progression Markers Initiative (PPMI). METHODS: Using whole blood, we characterized longitudinal differences in DNAm between sporadic PD patients (n = 196) and HCs (n = 86) enrolled in PPMI. RNA sequencing (RNAseq) was used to conduct gene...

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PMID: 38563317
DOI: 10.1002/ana.26923

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