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Parkinson’s disease-associated alterations in DNA methylation and hydroxymethylation in human brain

22 Dec 2025

Abstract excerpt

Epigenetic mechanisms mediate interactions between aging, genetics, and environmental factors in sporadic Parkinson's disease (PD). While multiple studies have explored DNA modifications in PD, few focus on 5-hydroxymethylcytosine (5hmc), which is important in the central nervous system and sensitive to environmental exposures. Existing studies have not differentiated between 5-methylcytosine (5mc) and 5hmc or...

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PMID: 41430078
DOI: 10.1038/s41531-025-01209-3

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