Article

On the molecular mechanism of SARS-CoV-2 retention in the upper respiratory tract

2020-07-29

Abstract excerpt

Cell surface receptor engagement is a critical aspect of viral infection. At low pH, binding of SARS-CoV and its ACE2 receptor has a tight interaction that catalyzes the fusion of the spike and endosomal membranes followed by genome release. Largely overlooked has been the role of neutral pH in the respiratory tract, where we find that SARS-CoV stabilizes a transition state that enhances the off-rate from its rece...

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Literature Corpus work: 8f0d5782-5a45-5e73-9851-685f70fbbada
DOI: 10.1101/2020.07.29.227389

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