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Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2

5 Feb 2021

Abstract excerpt

Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly to human and pangolin ACE2 receptors. We also report the cryo-EM structure of a Pangolin-CoV spike protein and show it adopts a fully-closed conformation and that, aside from the Receptor-Binding Domain, it...

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Animal Virus Infections Studies
SARS-CoV-2 and COVID-19 Research
Viral Infections and Outbreaks Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33547281
DOI: 10.1038/s41467-021-21006-9

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