Article

Loss of pH switch unique to SARS-CoV2 supports unfamiliar virus pathology

2020-06-23

Abstract excerpt

Cell surface receptor engagement is a critical aspect of viral infection. This paper compares the dynamics of virus-receptor interactions for SARS-CoV (CoV1) and CoV2. At low (endosomal) pH, the binding free energy landscape of CoV1 and CoV2 interactions with the angiotensin-converting enzyme 2 (ACE2) receptor is almost the same. However, at neutral pH the landscape is different due to the loss of a pH-switch (His...

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Literature Corpus work: 77ed8d6f-448f-52ce-8810-e6ff494f8c0a
DOI: 10.1101/2020.06.16.155457

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