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Article

SARS-CoV-2 Replication in Airway Epithelia Requires Motile Cilia and Microvillar Reprogramming

2022-04-26

Abstract excerpt

How SARS-CoV-2 penetrates the airway barrier of mucus and periciliary mucins to infect the nasal epithelium remains unclear. Using infection of primary nasal epithelial organoid cultures, we show that the virus attaches to motile cilia at the ACE2 receptor. SARS-CoV-2 traverses the mucus layer, using motile cilia as tracks to access the cell body, and depletion of cilia blocks infection. After the initial infectio...

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Literature Corpus work
fc35e620-6a64-5e89-8bec-1a7635be6971
DOI
10.2139/ssrn.4089984
Open publication

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