Article

A model for pH coupling of the SARS-CoV-2 spike protein open/closed equilibrium

2020-11-01

Abstract excerpt

SARS-CoV-2, causative agent of the COVID-19 pandemic, is thought to release its RNA genome at either the cell surface or within endosomes, the balance being dependent on spike protein stability, and the complement of receptors, co-receptors and proteases. To investigate possible mediators of pH-dependence, pKa calculations have been made on a set of structures for spike protein ectodomain and fragments from SARS-C...

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Literature Corpus work: 48ab396b-5023-59c0-a41b-cf064e8316b3
DOI: 10.1101/2020.10.31.363176

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