Article

IGF2BP3 is essential for the growth heterogeneity of colorectal adenoma cells by regulating MYC

2025-09-12

Abstract excerpt

Adenoma is a major precancerous lesion in colorectal cancer (CRC), and the adenoma-carcinoma sequence is a well-known multistep progression to CRC caused by the accumulation of genetic mutations. On the other hand, the non-genetic mechanisms in the adenoma-carcinoma sequence remain largely unknown. In this study, organoids were established from 31 colorectal adenomas from 19 patients. Some adenomas showed heteroge...

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Literature Corpus work: 8ed6578c-ac54-5512-b982-13dddfb58757
DOI: 10.1101/2025.09.08.674833

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