Article
Evaluation of the RAS signaling network in response to MEK inhibition using organoids derived from a familial adenomatous polyposis patient.
Scientific reports - 15 Oct 2020
Osumi Hiroki, Muroi Atsushi, Sakahara Mizuho, Kawachi Hiroshi, Okamoto Takuya, Natsume Yasuko, Yamanaka Hitomi, Takano Hiroshi, Kusama Daisuke, Shinozaki Eiji, Ooki Akira, Yamaguchi Kensei, Ueno Masashi, Takeuchi Kengo, Noda Tetsuo, Nagayama Satoshi, Koshikawa Naohiko, Yao Ryoji
Abstract excerpt
RAS signaling is a promising target for colorectal cancer (CRC) therapy, and a variety of selective inhibitors have been developed. However, their use has often failed to demonstrate a significant benefit in CRC patients. Here, we used patient-derived organoids (PDOs) derived from a familial adenomatous polyposis (FAP) patient to analyze the response to chemotherapeutic agents targeting EGFR, BRAF and MEK. We...
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