Evaluation of Mutation Risk Using Patient-Derived Organoids in Patients With Lynch Syndrome.

Abstract excerpt

Lynch syndrome (LS) is a hereditary cancer predisposition syndrome caused by germline mutation of DNA mismatch repair (MMR) genes, most notably associated with colorectal cancer. Although LS patients face high risk of CRC, risk can vary even among those with the same pathogenic MMR germline mutations. We suggest a functional assay platform for assessing mutation risk using patient-derived organoid (PDOs). We...

Topics

• Humans
• Organoids
• Colorectal Neoplasms, Hereditary Nonpolyposis
• Apoptosis
• DNA Damage
• Methylnitronitrosoguanidine