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Article

Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures

29 Mar 2019

Abstract excerpt

Organoid cultures derived from colorectal cancer (CRC) samples are increasingly used as preclinical models for studying tumor biology and the effects of targeted therapies under conditions capturing in vitro the genetic make-up of heterogeneous and even individual neoplasms. While 3D cultures are initiated from surgical specimens comprising multiple cell populations, the impact of tumor heterogeneity on drug...

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PMID: 30925167
DOI: 10.1371/journal.pgen.1008076

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