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IGF2BP3 promotes progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m6A-dependent mechanism

2022-02-01

Abstract excerpt

<h4>Background: </h4> Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an RNA-binding protein, is associated with tumorigenesis and progression. However, the exact molecular mechanisms of IGF2BP3 in colorectal cancer (CRC) oncogenesis, progression, and drug resistance remain largely unclear. <h4>Methods: </h4>: Transcriptome-sequencing, bioinformatics analysis, Western blot, and immunohistochemistry...

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Literature Corpus work
557c830f-ada4-5707-8fcf-dea63e19e0f8
DOI
10.21203/rs.3.rs-1297958/v1
Open publication

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IGF2BP3 promotes progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m6A-dependent mechanismDOI 10.21203/rs.3.rs-1297958/v1
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