Characterizing genomic alterations in cancer by complementary functional associations.

doi:10.1038/nbt.3527

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Article

Characterizing genomic alterations in cancer by complementary functional associations.

Nature biotechnology - 1 May 2016

Kim Jong Wook, Botvinnik Olga B, Abudayyeh Omar, Birger Chet, Rosenbluh Joseph, Shrestha Yashaswi, Abazeed Mohamed E, Hammerman Peter S, DiCara Daniel, Konieczkowski David J, Johannessen Cory M, Liberzon Arthur, Alizad-Rahvar Amir Reza, Alexe Gabriela, Aguirre Andrew, Ghandi Mahmoud, Greulich Heidi, Vazquez Francisca, Weir Barbara A, Van Allen Eliezer M, Tsherniak Aviad, Shao Diane D, Zack Travis I, Noble Michael, Getz Gad, Beroukhim Rameen, Garraway Levi A, Ardakani Masoud, Romualdi Chiara, Sales Gabriele, Barbie David A, Boehm Jesse S, Hahn William C, Mesirov Jill P, Tamayo Pablo

Abstract excerpt

Systematic efforts to sequence the cancer genome have identified large numbers of mutations and copy number alterations in human cancers. However, elucidating the functional consequences of these variants, and their interactions to drive or maintain oncogenic states, remains a challenge in cancer research. We developed REVEALER, a computational method that identifies combinations of mutually exclusive genomic...

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PMID: 27088724
DOI: 10.1038/nbt.3527
PMCID: PMC4868596

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