Article

Targeting CD38 effectively prevents myelofibrosis in myeloproliferative neoplasms

2025-03-03

Abstract excerpt

Proinflammatory signaling is a hallmark of myeloproliferative neoplasms (MPNs). Several studies have shown that monocytes are a major source of proinflammatory cytokines and monocyte-derived fibrocytes play a pivotal role in the pathogenesis of myelofibrosis (MF). To further explore the role of monocytes in MF, we generated inducible Nras G12D/+ Jak2 V617F/+ (NJ) mice. Recipients transplanted with NJ bone marro...

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Literature Corpus work: 8ed3da58-4880-5149-95de-b6f2fc486f8f
DOI: 10.1101/2025.03.02.639410

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