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Article

Quantitative assessment of innate myeloid cells in myelofibrosis: insights into myeloid and plasmacytoid dendritic cell depletion and disease progression.

Annals of hematology - 1 Dec 2025

Silva Nathália Aparecida Cavalcante, Guirao Fábio Pinotti, Barbosa Míriam Cristina Rodrigues, Bernal Diego Alonso Olavarría, Vassalli Laura Coutinho, Sandes Alex Freire

Abstract excerpt

Myelofibrosis (MF) is a myeloproliferative neoplasm characterized by bone marrow fibrosis, abnormal hematopoiesis, and extramedullary hematopoiesis. Abnormalities of the tumor microenvironment and immune system may be involved in the MF physiopathology and progression, particularly affecting innate myeloid cells (IMCs) such as myeloid dendritic cells (mDCs), plasmacytoid dendritic cells (pDCs) and monocytes. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41410775
DOI: 10.1007/s00277-025-06463-2
PMCID: PMC12764507

Genes

JAK2

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