Pacritinib prevents inflammation-driven myelofibrosis-like phenotype in a miR-146a-/- murine model.

doi:10.1016/j.biopha.2024.117712

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Article

Pacritinib prevents inflammation-driven myelofibrosis-like phenotype in a miR-146a-/- murine model.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Dec 2024

Cuenca-Zamora Ernesto José, Martínez Constantino, Morales María Luz, Guijarro-Carrillo Pedro Jesús, López-Poveda María José, Alcolea-Guardiola Carlos, Vidal-Garrido Natalia, Lozano María Luisa, Gonzalez-Conejero Rocío, Teruel-Montoya Raúl, Ferrer-Marín Francisca

Abstract excerpt

Chronic proinflammatory signaling is a characteristic trait in myeloproliferative neoplasms (MPN), particularly myelofibrosis (MF). Aberrant inflammatory signaling, particularly from NF-κB pathway, exacerbates the progression of MPN. Previously, we identified a critical role of miR-146a, a negative regulator of the TLR/NF-κB axis, in MF development. MPN patients carrying the miR-146a rs2431697-TT genotype,...

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PMID: 39603040
DOI: 10.1016/j.biopha.2024.117712

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