Article
Cellular and Molecular Mechanisms of Autoimmunity and Lupus Nephritis.
International review of cell and molecular biology - 1 Jan 2017
Devarapu S K, Lorenz G, Kulkarni O P, Anders H-J, Mulay S R
Abstract excerpt
Autoimmunity involves immune responses directed against self, which are a result of defective self/foreign distinction of the immune system, leading to proliferation of self-reactive lymphocytes, and is characterized by systemic, as well as tissue-specific, inflammation. Numerous mechanisms operate to ensure the immune tolerance to self-antigens. However, monogenetic defects or genetic variants that weaken immune...
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