Functions of SRPK , CLK and DYRK kinases in stem cells, development, and human developmental disorders

Abstract excerpt

Human developmental disorders encompass a wide range of debilitating physical conditions and intellectual disabilities. Perturbation of protein kinase signalling underlies the development of some of these disorders. For example, disrupted SRPK signalling is associated with intellectual disabilities, and the gene dosage of DYRKs can dictate the pathology of disorders including Down's syndrome. Here, we review the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Down syndrome and intellectual disability research
• Share to Genetics and Neurodevelopmental Disorders
• Share to Genomic variations and chromosomal abnormalities