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Protein phosphatase SCP4 regulates cartilage development and endochondral osteogenesis via FoxO3a dephosphorylation

17 Jun 2024

Abstract excerpt

Abstract The regulatory mechanisms involved in embryonic development are complex and yet remain unclear. SCP4 represents a novel nucleus‐resident phosphatase identified in our previous study. The primary aim of this study was to elucidate the function of SCP4 in the progress of cartilage development and endochondral osteogenesis. SCP4−/− and SCP4Col2ER mice were constructed to assess differences in bone formation...

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PMID: 38886174
DOI: 10.1111/cpr.13691

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