Article

Loss of Panx1 Function in Zebrafish Alters Motor Behavior in a Lab-on-Chip Model of Parkinson's Disease

2022-12-15

Abstract excerpt

Pannexin 1 (Panx1) forms ATP-permeable membrane channels that play essential roles in purinergic signaling in the nervous system. Several studies suggest a link between Panx1-based channels activity and neurodegenerative disorders including Parkinson’s disease (PD), but experimental evidence is limited. Here, we applied behavioral and molecular screening of zebrafish larvae to examine the role of Panx1 in both pat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c88361b9-b254-5847-8a97-ddfd2543dd78
DOI: 10.22541/au.167109848.86499277/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of Panx1 Function in Zebrafish Alters Motor Behavior in a Lab-on-Chip Model of Parkinson's DiseaseDOI 10.22541/au.167109848.86499277/v1Read

Phenotypic chemical and mutant screening of zebrafish larvae using an on-demand response to electric stimulation.Semantic proximity Read

<i>Panx1</i> channels promote both anti- and pro-seizure-like activities in the zebrafish via <i>p2rx7</i> receptors and ATP signalingSemantic proximity Read

1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine induced Parkinson's disease in zebrafishSemantic proximity Read

Panx1 Ablation Aggravates Oxidative Stress and Cell Death by Altering AMPK/mTOR signaling Pathways and the Composition of Synapses in the ZebrafishSemantic proximity Read

A Critical Review of Zebrafish Models of Parkinson’s DiseaseSemantic proximity Read

Studying the Pathophysiology of Parkinson’s Disease Using ZebrafishSemantic proximity Read

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-Treated Adult Zebrafish as a Model for Parkinson’s DiseaseSemantic proximity Read

Early motor deficits, sleep dysfunction and reduction in dopaminergic neurons in a park7 -/- zebrafish larval model of Parkinson’s diseaseSemantic proximity Read

Big Lessons from Tiny Flies:<em> Drosophila Melanogaster </em>as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter SystemsSemantic proximity Read

Loss of PINK1 in medaka fish (Oryzias latipes) causes late-onset decrease in spontaneous movement.Semantic proximity Read

Integrated Behavioral and Proteomic Characterization of MPP⁺-Induced Early Neurodegeneration and Parkinsonism in Zebrafish LarvaeSemantic proximity Read

Phenotypic Profiling of MPTP-Induced Parkinsonian-like Behavioral Phenotypes in Zebrafish Larvae Based on Behavioral Experiment.Semantic proximity Read