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Article

Pannexin-1 Deficiency Decreases Epileptic Activity in Mice.

International journal of molecular sciences - 12 Oct 2020

Aquilino Mark S, Whyte-Fagundes Paige, Lukewich Mark K, Zhang Liang, Bardakjian Berj L, Zoidl Georg R, Carlen Peter L

Abstract excerpt

OBJECTIVE: Pannexin-1 (Panx1) is suspected of having a critical role in modulating neuronal excitability and acute neurological insults. Herein, we assess the changes in behavioral and electrophysiological markers of excitability associated with Panx1 via three distinct models of epilepsy. Methods Control and Panx1 knockout C57Bl/6 mice of both sexes were monitored for their behavioral and electrographic...

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Identifiers

PMID: 33053775
DOI: 10.3390/ijms21207510
PMCID: PMC7589538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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