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Article

Lineage-Specific Epigenomic and Genomic Activation of the Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas

2019-10-21

Abstract excerpt

<h4>Backgrounds</h4> Gastrointestinal adenocarcinomas (GIACs) of the tubular GI tract including esophagus, stomach, colon and rectum comprise most GI cancers and share a spectrum of genomic features. However, the unified epigenomic changes specific to GIACs are less well-characterized.We applied mathematical algorithms to large-scale DNA methylome and transcriptome profiles to reconstruct transcription factor (TF...

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Literature Corpus work
8ec37d63-dd97-5a93-8f96-40bce50cc082
DOI
10.1101/812149
Open publication

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Lineage-Specific Epigenomic and Genomic Activation of the Oncogene HNF4A Promotes Gastrointestinal AdenocarcinomasDOI 10.1101/812149
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