Article
Subtypes of Barrett's oesophagus and oesophageal adenocarcinoma based on genome-wide methylation analysis.
Gut - 1 Mar 2019
Yu Ming, Maden Sean K, Stachler Matthew, Kaz Andrew M, Ayers Jessica, Guo Yuna, Carter Kelly T, Willbanks Amber, Heinzerling Tai J, O'Leary Rachele M, Xu Xinsen, Bass Adam, Chandar Apoorva K, Chak Amitabh, Elliott Robin, Willis Joseph E, Markowitz Sanford D, Grady William M
Abstract excerpt
OBJECTIVE: To identify and characterise DNA methylation subtypes in oesophageal adenocarcinoma (EAC) and its precursor Barrett's oesophagus (BE). DESIGN: We performed genome-wide DNA methylation profiling on samples of non-dysplastic BE from cancer-free patients (n=59), EAC (n=23), normal squamous oesophagus (n=33) and normal fundus (n=9), and identified methylation subtypes using a recursively partitioned...
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