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Article

A common pathway to cancer: Oncogenic mutations abolish p53 oscillations.

Progress in biophysics and molecular biology - 1 Oct 2022

Xiong Lingyun, Garfinkel Alan

Abstract excerpt

The tumor suppressor p53 oscillates in response to DNA double-strand breaks, a behavior that has been suggested to be essential to its anti-cancer function. Nearly all human cancers have genetic alterations in the p53 pathway; a number of these alterations have been shown to be oncogenic by experiment. These alterations include somatic mutations and copy number variations as well as germline polymorphisms....

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PMID: 35752348
DOI: 10.1016/j.pbiomolbio.2022.06.002

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