Article
Stress-specific response of the p53-Mdm2 feedback loop.
BMC systems biology - 12 Jul 2010
Hunziker Alexander, Jensen Mogens H, Krishna Sandeep
Abstract excerpt
BACKGROUND: The p53 signalling pathway has hundreds of inputs and outputs. It can trigger cellular senescence, cell-cycle arrest and apoptosis in response to diverse stress conditions, including DNA damage, hypoxia and nutrient deprivation. Signals from all these inputs are channeled through a single node, the transcription factor p53. Yet, the pathway is flexible enough to produce different downstream gene...
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