The p53 functional circuit

Abstract excerpt

The p53 gene is a tumor suppressor gene that plays a critical role in safeguarding the integrity of the genome. p53 is mutated or part of its regulatory circuit is functionally inactivated in almost all cancers, which highlights its importance in preventing tumorigenesis. The p53 protein is a sequence-specific DNA-binding transcription factor that is kept at a low level in cells under normal circumstances....

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