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Article

Dynamics of DNA Damage Induced Pathways to Cancer

4 Sept 2013

Abstract excerpt

Chemotherapy is commonly used in cancer treatments, however only 25% of cancers are responsive and a significant proportion develops resistance. The p53 tumour suppressor is crucial for cancer development and therapy, but has been less amenable to therapeutic applications due to the complexity of its action, reflected in 66,000 papers describing its function. Here we provide a systematic approach to integrate...

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PMID: 24023735
DOI: 10.1371/journal.pone.0072303

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