Article

Functional discovery of targetable dependencies in recurrent glioblastoma

2022-07-22

Abstract excerpt

<title>Abstract</title> <p>Resistance to genotoxic therapies and tumor recurrence are hallmarks of glioblastoma (GBM), an aggressive brain tumor. Here, we explore the functional drivers of post-treatment recurrent GBM. By conducting genome-wide CRISPR-Cas9 screens in patient-derived GBM models, we uncover distinct genetic dependencies in recurrent tumor cells that were absent in their patient-matched primary pred...

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Literature Corpus work: 8eb031db-985f-5174-8bc9-7d5890eacd42
DOI: 10.21203/rs.3.rs-1871890/v1

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