Article

REIIBP promotes TLR7-BTK-IL6 pro-inflammatory response through histone H3 lysine methylation in t(4;14) myelomagenesis

2022-04-13

Abstract excerpt

<h4>Background: </h4> Recurrent chromosomal translocations are central to the pathogenesis of Multiple Myeloma (MM), and the t(4;14) translocation is an adverse prognostic factor found in approximately 15% of MM patients. REIIBP is a t(4;14)-deregulated histone methyltransferase arising from alternative promoter usage within the MMSET locus. The role of this short isoform in t(4;14) myelomagenesis is poorly unders...

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Literature Corpus work: 8ea37904-da7e-5426-b47d-168e3b3af7cd
DOI: 10.21203/rs.3.rs-1539915/v1

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