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Article

The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma

18 Feb 2021

Abstract excerpt

Multiple myeloma is a malignancy of plasma cells initiated and driven by primary and secondary genetic events. However, myeloma plasma cell survival and proliferation might be sustained by non-genetic drivers. Z-DNA-binding protein 1 (ZBP1; also known as DAI) is an interferon-inducible, Z-nucleic acid sensor that triggers RIPK3-MLKL-mediated necroptosis in mice. ZBP1 also interacts with TBK1 and the transcription...

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PMID: 33596642
DOI: 10.3324/haematol.2020.274480

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