Article

Microhomology-mediated end joining drives complex rearrangements and over-expression of <i>MYC</i> and <i>PVT1</i> in multiple myeloma

2019-01-10

Abstract excerpt

MYC is a widely acting transcription factor and its deregulation is a crucial event in many human cancers. MYC is important biologically and clinically in multiple myeloma, but the mechanisms underlying its dysregulation are poorly understood. We show that MYC rearrangements are present in 36.0% of newly diagnosed myeloma patients, as detected in the largest set of next generation sequencing data to date (n=1267...

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Literature Corpus work: a07ecb6b-f91a-5637-a66f-e6274c97aee4
DOI: 10.1101/515106

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