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Article

NSD2-epigenomic reprogramming and maintenance of plasma cell phenotype in t(4;14) myeloma.

Oncotarget - 21 Mar 2025

Gunnell Andrea, Kimber Scott T, Houlston Richard, Kaiser Martin

Abstract excerpt

Overexpression of the H3K36 histone methyltransferase NSD2 in t(4;14) multiple myeloma (MM) is an early, oncogenic event, and understanding its impact on genomic organisation and expression is relevant to understanding MM biology. We performed epigenetic, transcriptional and phenotypic profiling of the t(4;14) KMS11 myeloma cell line and its isogenic translocation knock out (TKO) to characterise the sequelae of...

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Topics

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Share to Chromosomes, Human, Pair 14
Share to Chromosomes, Human, Pair 4
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenomics

Share to Histone-Lysine N-Methyltransferase

Share to Multiple Myeloma

Share to Plasma Cells

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 40116454
DOI: 10.18632/oncotarget.28706
PMCID: PMC11927793

Genes

NSD2
CD38
LAIR1
PRDM1
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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