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Article

MMSET is the key molecular target in t(4;14) myeloma

3 May 2013

Abstract excerpt

The t(4;14)(p16.3;q32.3) is found in 15% of presenting multiple myeloma (MM) cases and is associated with a significantly worse prognosis than other biological subgroups. As a consequence of the translocation, two genes are aberrantly expressed, the fibroblast growth factor receptor 3 ( FGFR3 ) and a multiple myeloma SET domain containing protein, MMSET ( WHSC1/NSD2 ), both of which have potential oncogenic...

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PMID: 23645128
DOI: 10.1038/bcj.2013.9

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