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Article

MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells

5 Dec 2008

Abstract excerpt

BACKGROUND: The recurrent immunoglobulin translocation, t(4;14)(p16;q32) occurs in 15% of multiple myeloma patients and is associated with poor prognosis, through an unknown mechanism. The t(4;14) up-regulates fibroblast growth factor receptor 3 (FGFR3) and multiple myeloma SET domain (MMSET) genes. The involvement of MMSET in the pathogenesis of t(4;14) multiple myeloma and the mechanism or genes deregulated by...

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PMID: 19059936
DOI: 10.3324/haematol.13426

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