Article

Different alleles of the same gene vary in pleiotropy, often mediated through currency metabolite production

2018-03-14

Abstract excerpt

A major obstacle to the mapping of genotype-phenotype relationships is pleiotropy, the tendency of mutations to affect seemingly unrelated traits. Pleiotropy has major implications for evolution, development, ageing, and disease. Except for disease data, pleiotropy is almost exclusively estimated from full gene knockouts. However, most deleterious alleles segregating in natural populations do not fully abolish gen...

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Literature Corpus work: 8e968bbb-aba0-54a7-bfb6-5d4a6cca660e
DOI: 10.1101/144329

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