Low frequency of mutations with strongly deleterious but nonlethal fitness effects.

Abstract excerpt

Most experimentally detectable effects of mutations in cellular organisms are either lethal or mildly deleterious. A possible explanation for the paucity of strongly detrimental but nonlethal mutations is that the processes constituting cellular metabolism are either essential or largely redundant. Alternatively, the partition between lethal and inconspicuous mutations exists within important biological...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Deletion
• Share to Genome, Fungal
• Share to Mutation