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Elucidating the CodY regulon in Staphylococcus aureus USA300 substrains TCH1516 and LAC

31 Aug 2023

Abstract excerpt

ABSTRACT CodY is a conserved broad-acting transcription factor that regulates the expression of genes related to amino acid metabolism and virulence in Gram-positive bacteria. Here, we performed the first in vivo determination of CodY target genes using a novel CodY monoclonal antibody in methicillin-resistant Staphylococcus aureus (MRSA) USA300. Our results showed (i) the same 135 CodY promoter binding sites...

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PMID: 37310465
DOI: 10.1128/msystems.00279-23

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