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Strain variation in <i>Clostridioides difficile</i> toxin activity associated with genomic variation at both PaLoc and non-PaLoc loci

2021-12-09

Abstract excerpt

<h4>ABSTRACT</h4> Clinical disease from Clostridioides difficile infection can be mediated by two toxins and their neighboring regulatory genes encoded within the five-gene pathogenicity locus (PaLoc). We provide several lines of evidence that the toxin activity of C. difficile may be modulated by genomic variants outside of the PaLoc. We used a phylogenetic tree-based approach to demonstrate discordance betwee...

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Literature Corpus work
535e0eb1-d2ee-56ed-b49f-408cb22d6c4e
DOI
10.1101/2021.12.08.471880
Open publication

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Strain variation in <i>Clostridioides difficile</i> toxin activity associated with genomic variation at both PaLoc and non-PaLoc lociDOI 10.1101/2021.12.08.471880
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