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Article

Repression of <i>Clostridium difficile</i> toxin gene expression by CodY

28 Aug 2007

Abstract excerpt

CodY, a global regulator of gene expression in low G + C Gram-positive bacteria, was found to repress toxin gene expression in Clostridium difficile. Inactivation of the codY gene resulted in derepression of all five genes of the C. difficile pathogenicity locus during exponential growth and stationary phase. CodY was found to bind with high affinity to a DNA fragment containing the promoter region of the tcdR...

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PMID: 17725558
DOI: 10.1111/j.1365-2958.2007.05906.x

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