Article

Kinetic and structural characterization of human NUDIX hydrolases NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis

2023-11-29

Abstract excerpt

<h4>ABSTRACT</h4> Isoprene pyrophosphates play a crucial role in the synthesis of a diverse array of essential nonsterol and sterol biomolecules, and serve as substrates for post-translational isoprenylation of proteins, enabling specific anchoring to cellular membranes. Hydrolysis of isoprene pyrophosphates would be a means to modulate their levels, downstream products, and protein isoprenylation. While NUDIX hy...

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Literature Corpus work: 8e7853fc-e3ce-5429-939e-2dae74f654ad
DOI: 10.1101/2023.11.29.569174

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Kinetic and structural characterization of human NUDIX hydrolases NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysisDOI 10.1101/2023.11.29.569174Read

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