Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of NUDIX Hydrolases in NAD and ADP-Ribose Metabolism in Mammals

1 Aug 2020

Abstract excerpt

Proteins of the NUDIX hydrolase (NUDT) superfamily that cleave organic pyrophosphates are found in all classes of organisms, from archaea and bacteria to higher eukaryotes. In mammals, NUDTs exhibit a wide range of functions and are characterized by different substrate specificity and intracellular localization. They control the concentration of various metabolites in the cell, including key regulatory molecules...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine and Purinergic Signaling
Share to Calcium signaling and nucleotide metabolism
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33045949
DOI: 10.1134/s0006297920080040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of NUDIX Hydrolases in NAD and ADP-Ribose Metabolism in MammalsPMID 33045949Read ↗

Comprehensive analysis of cytosolic Nudix hydrolases in Arabidopsis thaliana.Semantic proximity Read ↗

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPATSemantic proximity Read ↗

Substrate ambiguity among the nudix hydrolases: biologically significant, evolutionary remnant, or both?Semantic proximity Read ↗

Analysis of ligand binding and resulting conformational changes in pyrophosphatase NUDT9.Semantic proximity Read ↗

The role of the NTPDase enzyme family in parasites: what do we know, and where to from here?Semantic proximity Read ↗

Versatile physiological functions of the Nudix Hydrolase family in berry development and stress response in grapevineSemantic proximity Read ↗

Kinetic and structural characterization of human NUDIX hydrolases NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysisSemantic proximity Read ↗

Processing of protein ADP-ribosylation by Nudix hydrolases.Semantic proximity Read ↗

Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies.Semantic proximity Read ↗

Hydrolase regulates NAD+ metabolites and modulates cellular redox.Semantic proximity Read ↗

Nicotinamide Adenine Dinucleotide Deficiency and Its Impact on Mammalian Development.Semantic proximity Read ↗

The macro domain protein family: structure, functions, and their potential therapeutic implications.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.