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Article

Structural elucidation of the cis-prenyltransferase NgBR/DHDDS complex reveals insights in regulation of protein glycosylation.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2020

Edani Ban H, Grabińska Kariona A, Zhang Rong, Park Eon Joo, Siciliano Benjamin, Surmacz Liliana, Ha Ya, Sessa William C

Abstract excerpt

Cis-prenyltransferase (cis-PTase) catalyzes the rate-limiting step in the synthesis of glycosyl carrier lipids required for protein glycosylation in the lumen of endoplasmic reticulum. Here, we report the crystal structure of the human NgBR/DHDDS complex, which represents an atomic resolution structure for any heterodimeric cis-PTase. The crystal structure sheds light on how NgBR stabilizes DHDDS through...

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Identifiers

PMID: 32817466
DOI: 10.1073/pnas.2008381117
PMCID: PMC7456142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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