Article

Structural basis for long-chain isoprenoids synthesis by <i>cis</i> -prenyltransferases

2021-10-21

Abstract excerpt

Isoprenoids are the largest group of natural products, found in all living organisms and play an essential role in numerous cellular processes. These compounds are synthesized by prenyltransferases, catalyzing the condensation reaction between an allylic diphosphate primer and a variable number of isopentenyl diphosphate (C 5 ) units. This superfamily of enzymes can be subdivided into trans - or cis -prenyltran...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 78741f90-3d42-52bc-85cb-53d72a5a681f
DOI: 10.1101/2021.10.21.465316

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural basis for long-chain isoprenoids synthesis by <i>cis</i> -prenyltransferasesDOI 10.1101/2021.10.21.465316Read

Structure of the human heterotetrameric <i>cis</i> -prenyltransferase complexSemantic proximity Read

cis-Prenyltransferase: New Insights into Protein Glycosylation, Rubber Synthesis, and Human DiseasesSemantic proximity Read

Structural elucidation of the cis-prenyltransferase NgBR/DHDDS complex reveals insights in regulation of protein glycosylation.Semantic proximity Read

Chain-length determination mechanism of isoprenyl diphosphate synthases and implications for molecular evolution.Semantic proximity Read

Polyprenyl diphosphate synthases.Semantic proximity Read

Integrative modelling of the full-length human dehydrodolichyl diphosphate synthase using a hybrid computational and experimental approachSemantic proximity Read

Structure-function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis.Semantic proximity Read

Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase complex.Semantic proximity Read

Kinetic and structural characterization of human NUDIX hydrolases NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysisSemantic proximity Read

An alternative mechanism of product chain-length determination in type III geranylgeranyl diphosphate synthase.Semantic proximity Read

Cryo-EM Structure of the Cyclase Domain and Evaluation of Substrate Channeling in a Bifunctional Class II Terpene SynthaseSemantic proximity Read

Product chain-length determination mechanism of Z,E-farnesyl diphosphate synthase.Semantic proximity Read