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Article

SLC-25A46 regulates mitochondrial fusion through the mitofusin protein FZO-1 and is essential for maintaining neuronal morphology.

Journal of cell science - 15 Jun 2025

Obinata Hiroyuki, Watanabe Taisei, Takahashi Hironori, Shimo Satoshi, Oda Toshiyuki, Sugimoto Asako, Niwa Shinsuke

Abstract excerpt

Mitochondria are dynamic organelles shaped by sequential fission and fusion events. The mitochondrial protein SLC25A46 has been identified as a causative gene for mitochondrial neuropathies. However, the function of SLC25A46 in mitochondrial morphogenesis remains controversial, with several reports suggesting it acts as a mitochondrial fission factor, whereas others propose it as a fusion factor. In this study,...

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Identifiers

PMID: 40444356
DOI: 10.1242/jcs.263571
PMCID: PMC12273626

Genes

SLC25A46

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