Article

Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST

2024-03-27

Abstract excerpt

<h4>SUMMARY</h4> Lysosomal storage diseases (LSDs) comprise ∼50 monogenic disorders marked by the buildup of cellular material in lysosomes, yet systematic global molecular phenotyping of proteins and lipids is lacking. We present a nanoflow-based multi-omic single-shot technology (nMOST) workflow that quantifies HeLa cell proteomes and lipidomes from over two dozen LSD mutants. Global cross-correlation analysis...

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Literature Corpus work: 8693ccce-ffdd-5c13-ba3c-0b6a69154e76
DOI: 10.1101/2024.03.26.586828

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